DGKG Gene(Protein Coding)

• This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DGKG (Diacylglycerol Kinase Gamma) is a Protein Coding gene. Among its related pathways are Phospholipase D signaling pathway and triacylglycerol biosynthesis. GO annotations related to this gene include calcium ion binding and diacylglycerol kinase activity. An important paralog of this gene is DGKI.

• Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.

• Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKG Gene

Regulatory Elements for DGKG Gene

Genomic Location for DGKG Gene

Genomic View for DGKG Gene

Genes around DGKG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

• 3q27.3 by Ensembl
• 3q27.2-q27.3 by Entrez Gene
• 3q27-q28 by HGNC

DGKG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

RefSeq DNA sequence for DGKG Gene

Protein Expression for DGKG Gene

Post-translational modifications for DGKG Gene

Other Protein References for DGKG Gene

Gene Families for DGKG Gene

Protein Domains for DGKG Gene

Molecular function for DGKG Gene

Enzyme Numbers (IUBMB) for DGKG Gene

Phenotypes for DGKG Gene

miRNA for DGKG Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DGKG Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKG Gene

No data available for Gene Ontology (GO) - Cellular Components for DGKG Gene

Pathways by source for DGKG Gene

No data available for SIGNOR curated interactions for DGKG Gene